Consanguinity and familial mental retardation.
نویسندگان
چکیده
Studies made in a group of patients with mental retardation showed that there was a high degree of parental consanguinity of the order of 30.3%. Index cases with parental consanguinity showed a relatively higher prevalence where more than one sib was affected. Cases with metabolic defects were also more common among cases with parental consanguinity. There is a need for studies in the general population in order to understand the biological significance of consanguinity.
منابع مشابه
Study of Maternal Age, Family History of Mental Retardation, Consanguinity in Mental Retardation
Mental retardation is significantly sub average intellectual functioning present from birth or early infancy, causing limitations in the ability to conduct normal activities of daily living. Level of mental retardation, maternal age, family history of mental retardation and consanguinity associated disorder was recorded from data given by parents or center of rehabilitation. Forty seven percent...
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Detailed family history obtained from 361 cases of severe mental retardation revealed that more than one sib was affected in a majority of the cases where consanguinity was present in more than one generation. The need for studies in general population is indicated for purposes of evolving strategies for genetic counselling.
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Mental retardation (MR) is one of the most frequently found major genetic disorders around the world, affecting 1-3% of the people in the general population. The recent advancement in molecular biology and cytogenetic study has made possible the identification of new genes for a variety of genetic disorders including autosomal recessive MR. Recessive genetic disorders are common in Pakistan due...
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عنوان ژورنال:
- Journal of medical genetics
دوره 13 1 شماره
صفحات -
تاریخ انتشار 1976